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Taking advantage of drug resistance, a new approach in the war on cancer
Liqin Wang, Rene Bernards
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7
Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
Keywords: cancer drug resistance genetic screens senescence targeted therapy
Design and analysis of Salisbury screens and Jaumann absorbers for solar radiation absorption
Xing FANG, C. Y. ZHAO, Hua BAO
Frontiers in Energy 2018, Volume 12, Issue 1, Pages 158-168 doi: 10.1007/s11708-018-0542-6
Keywords: thin films admittance loci solar absorber
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 768-780 doi: 10.1007/s11684-023-0982-1
Keywords: machine learning methods hypertrophic cardiomyopathy genetic risk
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 601-607 doi: 10.1007/s11684-018-0648-6
Keywords: diet genetic susceptibility obesity interaction
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4, Pages 863-889 doi: 10.1007/s11709-019-0523-9
Keywords: design optimization genetic algorithm multiple populations neural network
Research progress on genetic improvement of
Chuanping YANG
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4, Pages 391-401 doi: 10.15302/J-FASE-2017183
Keywords: Betula platyphylla genetic improvement molecular breeding seed orchard
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 305-318 doi: 10.15302/J-FASE-2017154
Keywords: aquaculture genomics genetic breeding progress
Search-and-replace editing of genetic information
Yao LIU, Xingxu HUANG, Xiaolong WANG
Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2, Pages 231-232 doi: 10.15302/J-FASE-2020322
Age-related trends in genetic parameters for wood properties in
Chao SUN, Meng LAI, Shougong ZHANG, Xiaomei SUN
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4, Pages 482-492 doi: 10.15302/J-FASE-2017184
Keywords: early selection genetic variation wood properties SilviScan Larix kaempferi
Optimal design of steel portal frames based on genetic algorithms
CHEN Yue, HU Kai
Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 4, Pages 318-322 doi: 10.1007/s11709-008-0055-1
Keywords: satisfactory genetic-algorithm-based Technical Specification algorithm efficiency
Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 3, Pages 378-395 doi: 10.1007/s11709-022-0899-9
Keywords: optimization surrogate models artificial neural network SAP2000 genetic algorithm
Advances in genetic engineering of domestic animals
Shaohua WANG,Kun ZHANG,Yunping DAI
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1, Pages 1-10 doi: 10.15302/J-FASE-2016085
Keywords: CRISPR TALEN ZFN gene editing livestock pig cattle
Plant genetic engineering and genetically modified crop breeding: history and current status
Xingchun WANG,Shujun CHANG,Jie LU,Rupert FRAY,Don GRIERSON,Yuanhuai HAN
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1, Pages 5-27 doi: 10.15302/J-FASE-2017131
Keywords: plant transformation transgene genetic modification
Pengxing YI,Lijian DONG,Tielin SHI
Frontiers of Mechanical Engineering 2014, Volume 9, Issue 4, Pages 354-367 doi: 10.1007/s11465-014-0319-5
Keywords: planet carrier multi-objective optimization genetic algorithms wind turbine gearbox modal experiment
Optimization and its realization of anneal-genetic algorithm
Wang Ying
Strategic Study of CAE 2008, Volume 10, Issue 7, Pages 57-59
Keywords: genetic algorithm simulated annealing algorithm genetic algorithm improvement
Title Author Date Type Operation
Taking advantage of drug resistance, a new approach in the war on cancer
Liqin Wang, Rene Bernards
Journal Article
Design and analysis of Salisbury screens and Jaumann absorbers for solar radiation absorption
Xing FANG, C. Y. ZHAO, Hua BAO
Journal Article
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
Journal Article
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
Journal Article
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
Journal Article
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
Journal Article
Search-and-replace editing of genetic information
Yao LIU, Xingxu HUANG, Xiaolong WANG
Journal Article
Age-related trends in genetic parameters for wood properties in
Chao SUN, Meng LAI, Shougong ZHANG, Xiaomei SUN
Journal Article
Optimal design of double-layer barrel vaults using genetic and pattern search algorithms and optimized
Journal Article
Advances in genetic engineering of domestic animals
Shaohua WANG,Kun ZHANG,Yunping DAI
Journal Article
Plant genetic engineering and genetically modified crop breeding: history and current status
Xingchun WANG,Shujun CHANG,Jie LU,Rupert FRAY,Don GRIERSON,Yuanhuai HAN
Journal Article
Multi-objective genetic algorithms based structural optimization and experimental investigation of the
Pengxing YI,Lijian DONG,Tielin SHI
Journal Article